Pathology Tests Explained


Feedback system

Also known as: Feedback mechanism, feedback loop

The body uses feedback systems to control certain functions. A feedback system uses one of the products of a pathway, usually the end product, to control the activity of the pathway and to regulate the amount of that product. Feedback control may be positive or negative.

A negative feedback system maintains a 'steady state' or equilibrium and is the one most commonly found in the body.

Positive feedback systems increase the rate of formation of the product. This tends to cause change in the system rather than maintain a steady state. There are very few positive feedback systems in the body. One example, however, is lactation. The suckling action of an infant produces prolactin, which leads to milk production; more suckling leads to more prolactin, which in turn leads to more lactation. This is a positive feedback system as the product (milk) produces more suckling and more hormone. When the child is no longer breast feeding, the prolactin drops off and milk production goes down.