At a glance
Also known as
Mesothelin; [previous name: soluble mesothelin-related peptides, SMRP]
Why get tested?
It is most often used to monitor progression or recurrence of a rare cancer called . The test may also be taken into consideration when planning further investigations of someone with a moderate likelihood of mesothelioma. Mesothelioma is a cancer that affects the membranes that surround the lungs, heart, and abdominal cavity. Most cases of mesothelioma are associated with asbestos exposure. It is not a screening test for asbestos exposure and is not used in children.
When to get tested?
After you have been diagnosed with mesothelioma, this test may be requested to follow response to treatment at anytime during or after treatment. When possible mesothelioma is being investigated the test may be used to help plan further investigations.
A blood sample drawn from a vein in the arm
What is being tested?
This test measures the amount of small molecules called serum mesothelin in the blood. These peptides are breakdown products from found in the membranes lining the cavities that surround the lungs, heart, and abdomen. High amounts of mesothelin are often seen in the blood of patients suffering from , and the amount of mesothelin in the blood is thought to be related to the extent of disease.
mesothelioma is a rare cancer of the membranes that cover the outside of internal organs and line body cavities, including the chest ( mesothelioma), abdominal cavity ( mesothelioma), and the heart ( mesothelioma). Pleural mesothelioma is the most common type, accounting for 90% of all cases. Most cases of pleural mesothelioma — about 70% to 80% — arise in patients with a history of working with asbestos, especially in the shipbuilding, construction, automotive, and fireproofing industries. The disease has a long latency period, meaning that patients usually develop mesothelioma 20 to 50 years after asbestos exposure.
How is the sample collected for testing?
A blood sample is taken by needle from a vein in the arm.
Is any test preparation needed to ensure the quality of the sample?
No test preparation is needed.